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09-Feb-2017 17:34

Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms.[9,10] Follicular lymphoma comprises 20% of all NHL and as many as 70% of the indolent lymphomas reported in American and European clinical trials.[1-3] Most patients with follicular lymphoma are age 50 years and older and present with widespread disease at diagnosis.

Nodal involvement is most common and is often accompanied by splenic and bone marrow disease.

The prognosis depends on the histologic type, stage, and treatment.

NHL can be divided into two prognostic groups: the indolent lymphomas and the aggressive lymphomas.

Knowledge of cell surface markers and immunoglobulin and T-cell receptor gene rearrangements may help with diagnostic and therapeutic decisions.

The clonal excess of light-chain immunoglobulin may differentiate malignant from reactive cells.

In general, with modern treatment of patients with NHL, overall survival at 5 years is over 60%.On a comparative basis, it is difficult to prove benefit when relapsing disease is followed with watchful waiting, or when the median survival is more than 10 years.Follicular lymphoma and primary follicular lymphoma of the duodenum are particularly indolent variants that rarely progress and rarely require therapy.[20,21] A so-called pediatric-type nodal follicular lymphoma has indolent behavior and rarely recurs; adult patients with this histologic variant are characterized by a lack of rearrangement in conjunction with a Ki-67 proliferation index greater than 30% and a localized stage I presentation.[22] Patients with indolent lymphoma may experience a relapse with a more aggressive histology.The non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment.[1] Like Hodgkin lymphoma, NHL usually originates in lymphoid tissues and can spread to other organs.



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