For elucidating


19-Feb-2017 11:22

Thus, there is a compelling need for an appropriate scoring function to evaluate the DNA-ZFP binding specificity in order to ensure that the predicted protein is the best choice for a given DNA target.

A simple measure to identify the hydrogen bonds formed in the complex, and to quantify their strengths in terms of interaction energies is desirable for the investigation of ZFP-DNA hydrogen bonded systems.

Another measure of specificity includes the comparison between the binding constant at the desired ZFP target site to that of the binding constant at various “mutant” sites wrt DNA.This motif has been found to be occurring in a large number of natural proteins that recognize specific DNA sites.Also, the covalent linkage of multiple DNA-binding domains and the fact that these proteins do not require symmetric binding sites offers a practical advantage in the designing of ZFPs derived from mutations in the Zif-268 protein template.The most common DNA-binding motif found in humans and multicellular organism is the cysteine-histidine (Cys2-His2) zinc finger.



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