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Figuring out how to trigger the injection was a challenge.
The answer came to me when I reached for an Alka Seltzer after a spicy Indian dinner.
When it reaches the intestine, the balloon inflates, prompting needles made of bioabsorbable materials — such as sugar — to be injected in the intestinal wall.
Mir Imran: The intestine offers an ideal location for optimal drug absorption into the bloodstream, and its lack of pain receptors make the approach painless.
had the opportunity to ask Mir Imran, Chairman and CEO of Rani Therapeutics, some questions about the technology.
Mir Imran is a prolific inventor of medical devices and has founded more than 20 life sciences companies.
If the pill could protect the drug until it reaches the intestine, and then inject the biologic into the intestinal wall — which has no sharp pain receptors — we could achieve successful administration without pain or loss of efficacy.
While previous attempts to convert injections into pills have relied exclusively on chemistry, Rani has approached this challenge with engineering. Mir Imran: The Rani pill is essentially a mini swallowable auto-injector that delivers the drug directly into the highly vascular intestinal wall, allowing the drug to be absorbed quickly into the bloodstream.
Mir Imran: The pill was designed with biologic drugs in mind, such as basal insulin, adalimumab, Human Interferon, and human growth hormone, each a multi-billion dollar market.For diabetic patients, who must inject insulin daily, this could mean that they don’t need to worry about needles and painful injections.The pill protects the drug inside itself until it reaches the intestine, where needles made of sugar emerge from the pill and inject the drug directly into the wall of the intestine. In some jurisdictions (like the US), other cookies (e.g., analytic or advertising cookies) may also be used (or authorized for third party use). Join today and receive: • Up to 20% off room rates • Pre-sale ticket offers to world-class entertainment • Discounts at participating retail shops • Access to exclusive M life Moments To view and book offer for Borgata Hotel Casino & Spa in Atlantic City, click here.