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In the mid-1970s, he began performing a "manic" style of stand-up, which got him noticed in 1977, and he landed a spot on the TV show Laugh-In.
Robin says the stress of stand-up triggered his alcohol and drug dependency early in his career.
But his best-known and perhaps best-loved role was in Mrs Doubtfire in 1993, in which he plays a father desperate to stay in his kids' lives, and pretends to be a female housemaid in order to do so.
He continued his string of family-friendly hits with Jumanji (1995), and the sci-fi caper Flubber (1997).
But Pam has said that she never took offence because he was so charming.
She described filming the show as “so much fun” and remarked: “It was the Seventies, after all.” Pam said: “I had the grossest things done to me - by him.
She says the first symptoms of the disease appeared in October 2013 and included fear and anxiety, constipation, urinary difficulty, heartburn, sleeplessness and insomnia, a poor sense of smell, stress, and a slight tremor in his left hand.
Eventually, he suffered problems with his memory, and with intense paranoia, with Susan commenting: "Robin was losing his mind and he was aware of it...
In a new biography about Robin, Pam Dawber said that the late actor repeatedly grabbed her bottom and breasts and took off his clothes in front of her whilst filming Mork and Mindy together.
After that, he played a rebellious robot in Bicentennial Man (1999), before taking on his most distinctive and surprising role as a troubled supermarket worker in thriller One Hour Photo (2002). “But somehow he had this guileless little thing that he would do - those sparkly eyes.
He also appeared in Christopher Nolan's Insomnia, and later in life voiced a character in both the Happy Feet movies, and played Theodore Roosevelt in three Night At The Museum movies. He’d look at you, really playful, like a puppy, all of a sudden.
Other TV work included The Richard Pryor Show, comedy special Off The Wall, Happy Days and his own spin-off show from Happy Days called Mork & Mindy, which was incredibly popular.
Then came his first major movie role, as the lead in 1980 film Popeye, and his Hollywood career took off after that.
He kept saying, ' I just want to reboot my brain.'" His tragic final days have been revealed in a new book which chronicles how his mind and body faded from an incurable brain disorder the actor was unaware he had.